CLOSTRIDIUM-DIFFICILE COLITIS AFTER AORTIC-SURGERY

Objective: To determine the incidence and outcome of Clostridium diffi cile colitis (CDC) following aortic surgery. Design: Retrospective cli nical study, and case-note review. Patients: Of 180 patients undergoin g aortic surgery for either aneurysmal or occlusive disease between 1 September 1994 and 31 August 1996 (24 months), 15 (8.4%) developed CDC . There were 12 male and three female patients of median age 65 (range 46-84). Results: Two patients died from multiple organ failure in ass ociation with CDC, one of whom underwent negative relaparotomy for sus pected ischaemic bowel because the diagnosis of CDC had not been enter tained Previously identified risk factors for CDC comprised: age >65 ( eight); renal impairment (four); chronic obstructive airways disease ( seven); coexistent malignancy (three); admission from another hospital (four); H-2 antagonist therapy (13); ITU (nine); and/or HDU care (14) . Diarrhoea commenced a median of 9 (range 5-26) days, and CDC, was di agnosed a median of 14 (range 10-26) days after operation. All patient s received intravenous Cefuroxime, originally prescribed as prophylaxi s, for a median of 6 (range 3-16) days prior to onset of CDC. Two pati ents received 1 additional antibiotic; one received 2; two received 3; and one received 4 prior to onset of CDC. Conclusions: CDC is a commo n and potentially serious complication of vascular, and in particular, aortic surgery. Although such patients often possess several risk fac tors for CDC, colitis frequently follows prolonged 'prophylactic' ceph alosporin administration, which should therefore be avoided.