ADVANCED-STAGE SMALL-CELL CARCINOMA OF THE OVARY IN PREGNANCY - LONG-TERM SURVIVAL AFTER SURGICAL DEBULKING AND MULTIAGENT CHEMOTHERAPY

We report the longest disease-free survival achieved in an advanced-st age small cell carcinoma of the ovary. The patient had a stage IIIc tu mor diagnosed during pregnancy. She underwent a total abdominal hyster ectomy, bilateral salpingo-oophorectomy, omentectomy, and optimal tumo r debulking. Following her immediate postoperative recovery, she was t reated with a multiagent chemotherapy regimen with germ cell activity consisting of vinblastine, cisplatin, cyclophosphamide, bleomycin, dox orubicin, and etoposide. She is alive and without evidence of disease 5 1/2 years after diagnosis. This is the second reported case in pregn ancy and the longest disease-free survivor of metastatic small cell ov arian carcinoma in the medical literature. (C) 1997 Academic Press.