THE EFFECT OF INTRAUTERINE DIETHYLSTILBESTROL EXPOSURE ON OVARIAN RESERVE SCREENING

OBJECTIVE: Our goal was to evaluate the effect of intrauterine diethyl stilbestrol exposure on ovarian reserve. STUDY DESIGN: Four hundred tw o women underwent ovarian reserve screening. Twenty had intrauterine d iethylstilbestrol exposure, and 382 women did not have exposure. The g roups were compared regarding age, the incidence of diminished ovarian reserve, and cycle length, Nine women with and 204 women without diet hylstilbestrol exposure underwent comparison of the total human menopa usal gonadotropin dose, the day of human chorionic gonadotropin admini stration, the peak estradiol level, and the number of mature follicles . RESULTS: The diethylstilbestrol-exposed women were similar in age (3 7 +/- 3.4 years) to the nondiethylsillbestrol-exposed women (35 +/- 4. 4 years, p > 0.05). Three of 20 exposed women (15.8%) and 57 of 382 no nexposed women (15.3%) had diminished ovarian reserve (p = 0.41). When the exposed women were compared with the nonexposed subjects, the amo unts of human menopausal gonadotropin (30 +/- 10 vs 33.7 +/- 10.6 ampu les) required to achieve peak estradiol levels (633 +/- 323 vs 817 +/- 518 pg/ml) with comparable numbers of follicles (5.7 +/- 2.7 vs 5.4 /- 2.8) on the day of human chorionic gonadotropin administration were similar (p > 0.05). CONCLUSIONS: The diethylstilbestrol-exposed and n onexposed women had a similar incidence of diminished ovarian reserve and a similar follicular response to gonadotropins.