PROLIFERATIVE RESPONSE OF T-LYMPHOCYTE AND B-LYMPHOCYTE OF 2 MOUSE STRAINS TREATED FOR EXPERIMENTAL LARVAL TOXOCAROSIS

The effect of liposomized albendazole on the proliferative response of splenic lymphocytes to T- and B-cell polyclonal activators (concanava lin A, lipopolysaccharide, pokeweed mitogen) was compared in inbred an d noninbred strains of mice with experimental toxocarosis. Differences between the two strains consisted in a higher inhibition of the proli ferative response of T and B lymphocytes and in its earlier onset in h ealthy inbred animals compared with non-inbred mice. In infected and t reated mice, inhibition of T cells was higher in non-inbred than in in bred strain and the inhibited proliferative response of B lymphocytes was preceded by its stimulation. The variation coefficient of the T-an d B-cell proliferative response was lower and less fluctuating in inbr ed (mean 3.0 %) than in non-inbred (mean 9.3 %) mice. The study strain s of mice also exhibited differences in the drug anthelmintic efficacy on migrating larvae of Toxocara canis (inbred strain: muscles 41.5-60 .8 %, brain 52.4-68.2 %; noninbred strain muscles 29.1-50.7 %, brain 5 .5-76.6 %). The results show differences in the immunomodulative effec t and anthelmintic efficacy of albendazole in mice with different gene tic equipment.