THEORY OF ADHESION INTERACTION OF BIOLOGICAL CELLS IN A LIQUID FLOW -INFLUENCE OF CELL-DEFORMATION ON COAGULATION

In the previous communication a theory was developed for the descripti on of the coagulation of colloid particles with different types of att ractive interaction caused by the shear flow. In this work, this theor y was applied to particles that may be deformed by increased hydrostat ic pressure in the gap between their surfaces in close contact in the shear flow. The suggested approach permitted the disturbance in the tr ajectories of the particles and the corrections for van der Waals forc es and for biospecific interactions caused by the elastic deformation of the particles to be considered. All of these factors lead to an inc rease in the efficiency of the intercapture of the particles at low sh ift rates and to its decrease at high shear rates. The efficiency, cal culated within the framework of this theory, of the capture of biologi cal cells was in good agreement with experimental data on the aggregat ion of activated blood thrombocytes, when the modulus of elasticity wa s 10(6) Pa by the order of magnitude. This result agreed with the lite rature data for the corresponding objects.