D. Slowinskaklencka et al., USEFULNESS OF COMPUTER-AIDED KARYOMETRIC EXAMINATION IN PREOPERATIVE DIFFERENTIATION OF HURTHLE CELL LESIONS, Diagnostic cytopathology, 17(4), 1997, pp. 255-257
We have previously reported that there is a significant difference in
the mean size of thyrocyte nuclei among patients with nodular goiter f
ollicular adenoma, and follicular carcinoma. In the present study we h
ave examined karyometric parameters of Hurthle cells in smears collect
ed from 41 patients with Hurthle cells adenomas, Hurthle cells carcino
mas, nodular goiter and lymphocytic thyroiditis. The karyometric evalu
ation was performed with the image analysis computer system-Karyometry
Manager 1.2. We measured the mean volume, the mean intel section area
, and rite mean perimeter of 100 nuclei in each routine smear. We Soun
d that the sizes of Hurthle cell nuclei could be arranged in the ascen
ding order from the nodular goiter through lymphocytic thyroiditis to
Hurthle cell neoplasms, but those differences did not I-each a border
of statistical significance. (C) 1997 Wiley-Liss, Inc.