4 NEW CLERODANE DITERPENES FROM THE LEAVES OF CASEARIA-GUIANENSIS WHICH INHIBIT THE INTERACTION OF LEUKOCYTE FUNCTION ANTIGEN-1 WITH INTERCELLULAR-ADHESION MOLECULE-1

Four new clerodane diterpenes, casearinols A and B (1 and 2) and casea rinones A and B (3 and 4), were isolated from the leaves of Casearia g uianensis. These immunomodulatory compounds have been structurally elu cidated primarily on the basis of 2D NMR analysis and spectral data co mparison with known compounds. These compounds inhibited the binding o f T-cell leukocyte function antigen 1 to intercellular adhesion molecu le 1.