STUDY ON CYTOTOXIC OXYGENATED DESMOSTEROLS ISOLATED FROM THE RED ALGAGALAXAURA-MARGINATA

Authors
SHEU JH HUANG SY WANG GH DUH CY
Citation
Jh. Sheu et al., STUDY ON CYTOTOXIC OXYGENATED DESMOSTEROLS ISOLATED FROM THE RED ALGAGALAXAURA-MARGINATA, Journal of natural products, 60(9), 1997, pp. 900-903
Citations number
14
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
9
Year of publication
1997
Pages
900 - 903
Database
ISI
SICI code
0163-3864(1997)60:9<900:SOCODI>2.0.ZU;2-X
Abstract
Four novel oxygenated desmosterols, 24 xi-hydroperoxy-6 beta-hydroxych olesta-4,25-dien-3-one (1), 25-hydroperoxy-6 beta-hydroxycholesta-4,23 (E)-dien-3-one (2), 24 xi-hydroperoxycholesta-4,25-diene-3,6-dione (3) , and 25-hydroperoxycholesta-4,23(E)-diene-3,6-dione (4) were isolated from the marine red alga Galaxaura marginata. Steroids 1-4 and three synthetic oxygenated desmosterols 5-7 were shown to exhibit significan t cytotoxicity against several cancer cell lines.