AN EFFICIENT ACCESS TO THE ENANTIOMERS OF ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE VIA A HYDANTOIN ROUTE USING A PRACTICAL VARIANT OF PREFERENTIAL CRYSTALLIZATION AS3PC (AUTO SEEDED PROGRAMMED POLYTHERMIC PREFERENTIAL CRYSTALLIZATION)

Authors
NDZIE E CARDINAEL P SCHOOFS AR COQUEREL G
Citation
E. Ndzie et al., AN EFFICIENT ACCESS TO THE ENANTIOMERS OF ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE VIA A HYDANTOIN ROUTE USING A PRACTICAL VARIANT OF PREFERENTIAL CRYSTALLIZATION AS3PC (AUTO SEEDED PROGRAMMED POLYTHERMIC PREFERENTIAL CRYSTALLIZATION), Tetrahedron : asymmetry, 8(17), 1997, pp. 2913-2920
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
17
Year of publication
1997
Pages
2913 - 2920
Database
ISI
SICI code
0957-4166(1997)8:17<2913:AEATTE>2.0.ZU;2-J
Abstract
The enantiomers are obtained in preparative amounts without a resolvin g agent via the following sequence: hydantoin synthesis, resolution by entrainment, and ring cleavage by means of hydrolysis in basic condit ions. The new variant of preferential crystallization (AS3PC), impleme nted without using seeds, shows good reproducibility and yield. (C) 19 97 Elsevier Science Ltd.