SURVIVAL OF A BACTERIOFERRITIN DELETION MUTANT OF BRUCELLA-MELITENSIS16M IN HUMAN MONOCYTE-DERIVED MACROPHAGES

Authors
DENOEL PA CRAWFORD RM ZYGMUNT MS TIBOR A WEYNANTS VE GODFROID F HOOVER DL LETESSON JJ
Citation
Pa. Denoel et al., SURVIVAL OF A BACTERIOFERRITIN DELETION MUTANT OF BRUCELLA-MELITENSIS16M IN HUMAN MONOCYTE-DERIVED MACROPHAGES, Infection and immunity, 65(10), 1997, pp. 4337-4340
Citations number
32
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
10
Year of publication
1997
Pages
4337 - 4340
Database
ISI
SICI code
0019-9567(1997)65:10<4337:SOABDM>2.0.ZU;2-D
Abstract
A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M wa s generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were simil ar to those of its parental strain in human monocyte-derived macrophag es (MDM). These results suggest that BFR is not essential for the intr acellular survival of B. melitensis in human MDM.