APOLIPOPROTEIN A(1) EXPRESSION IN YOUNG AND AGED RATS IS MODULATED BYDIETARY CARBOHYDRATES

To determine if dietary carbohydrates modulate apolipoprotein A(1) (Ap oA(1)) expression, plasma ApoA(1) protein and hepatic ApoA(1) mRNA lev els were measured in young and aged rats maintained on a high-fructose (60% of diet weight consisting of fructose), or high-glucose (60% glu cose) diet or fed regular rat chow for 10 days, Aged rats on regular c how had significantly higher plasma ApoA(1) concentrations and hepatic ApoA(1) mRNA than young rats maintained on this diet, Plasma ApoA(1) and hepatic ApoA(1) mRNA levels in young rats or aged rats maintained on the 60% fructose diet were significantly higher than in rats within the same age group maintained on regular rat chow (P < .01). Similar induction of ApoA(1) protein and mRNA was found in rats maintained on the 60% glucose diet (P < .01). It is concluded that ApoA(1) expressio n in rats is modulated by factors related to the nature of dietary car bohydrates rather than insulin resistance associated with high-fructos e feeding. Copyright (C) 1997 by W.B. Saunders Company.