R. Bossio et al., SYNTHESIS OF N,N'-DIARYLDIPEPTIDE AMIDES BY MULTICOMPONENT CONDENSATION UTILIZING POTASSIUM ISOCYANOACETATE, Synthesis, (7), 1994, pp. 672-674
The reaction between ketones 1, amine hydrochlorides 2, and potassium
isocyanoacetate (3) affords a series of dipeptide derivatives 5. The s
tructure of compounds 5 is in agreement with their spectral data and i
s confirmed by means of X-ray analysis of 5a.