REGIOSPECIFIC SYNTHESIS OF ALPHA-AMINO KETO ACETALS (BETA,BETA-DIALKOXYAMINES)

Authors
DEKIMPE N STANOEVA E
Citation
N. Dekimpe et E. Stanoeva, REGIOSPECIFIC SYNTHESIS OF ALPHA-AMINO KETO ACETALS (BETA,BETA-DIALKOXYAMINES), Synthesis, (7), 1994, pp. 695-697
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
7
Year of publication
1994
Pages
695 - 697
Database
ISI
SICI code
0039-7881(1994):7<695:RSOAKA>2.0.ZU;2-5
Abstract
alpha-Amino keto acetals (beta,beta-dialkoxyamines) are synthesized in a regiospecific way by the reaction of alpha-bromo-alpha-chloro ketim ines with sodium borohydride in methanol. As alpha-bromo-alpha-chloro ketimines are formed regiospecifically from alpha,alpha-dihalogenated ketones, derived from the corresponding ketones, this methodology enta ils a regiospecific synthesis of alpha-amino keto acetals from ketones .