RELATIONSHIP OF GENITAL WART BURDEN TO THERAPEUTIC RESPONSE TO FLUOROURACIL EPINEPHRINE INJECTABLE GEL/

The efficacy of a single cycle of a new therapy for genital warts, int radermal fluorouracil/epinephrine (5-FU/epi) injectable gel, has been evaluated in 2 large pivotal trials; the objective of this study was t o evaluate a second cycle of treatment. Twenty-two patients with total wart areas of 5-447 mm(2) were treated with up to 2 cycles of less th an or equal to 6 treatments of 5-FU/epi gel. After the first cycle of treatments, patients with warts showing a partial response or no respo nse or new warts were continued into a second cycle. Seventy-three per cent (16/22) of patients had complete responses. Patients with total wart areas less than or equal to 100 mm(2) tended to respond completel y in the first cycle of treatment (average 4.7 treatments). Patients w ith numerous warts or large total wart areas (> 100 mm(2)) required an average of 7.5 treatments to achieve a complete response. Thus, a sec ond treatment cycle may be appropriate for difficult-to-treat patients with numerous warts or large total wart areas.