EXACERBATION OF COAGULOPATHY WITH CONCURRENT BONE-MARROW NECROSIS, HEPATIC AND RENAL DYSFUNCTION SECONDARY TO ALL-TRANS-RETINOIC ACID THERAPY FOR ACUTE PROMYELOCYTIC LEUKEMIA

Authors
CULL GM EIKELBOOM JW CANNELL PK
Citation
Gm. Cull et al., EXACERBATION OF COAGULOPATHY WITH CONCURRENT BONE-MARROW NECROSIS, HEPATIC AND RENAL DYSFUNCTION SECONDARY TO ALL-TRANS-RETINOIC ACID THERAPY FOR ACUTE PROMYELOCYTIC LEUKEMIA, Hematological oncology, 15(1), 1997, pp. 13-17
Citations number
11
Categorie Soggetti
Hematology,Oncology
Journal title
Hematological oncology → ACNP
ISSN journal
02780232
Volume
15
Issue
1
Year of publication
1997
Pages
13 - 17
Database
ISI
SICI code
0278-0232(1997)15:1<13:EOCWCB>2.0.ZU;2-3
Abstract
A 22-year-old female presented with acute promyelocytic leukemia (APL) . Treatment with ail-trans retinoic acid (ATRA) resulted in a severe e xacerbation of the coagulopathy 5 days after its introduction. This wa s complicated by bone marrow necrosis, parenchymal liver damage and ac ute tubular necrosis. Temporary cessation of the drug and subsequent d ose reduction was effective in controlling the coagulopathy. (C) 1997 John Wiley & Sons, Ltd.