EFFECT OF ITRACONAZOLE ON LYTIC ANTIBODIES LEVELS IN CHRONIC CHAGAS-DISEASE

We report the chemotherapeutic effect of itraconazole in chronic chaga sic patients. The efficacy of treatment was analyzed by xenodiagnosis (XD), conventional serology (CS) and antibody dependent-complement med iated lysis test (CoML). Twenty chronic chagasic persons from endemic areas of Chile were grouped according to the results of xenodiagnosis (XD) performed before therapy. The follow-up of patients was performed at an average rime of 42 months after treatment. No significative sta tistical differences were observed in the result of ELISA and indirect Immunofluorescence test performed on sera before and after therapy wi th itraconazole. in the group of patients with positive XD before ther apy, sera from six of them displayed lytic activity against Trypanosom a cruzi. The lytic activity of only one of these sera became negative after therapy. In relation to XD, five of those patients showed a posi tive tests at least once during the follow-vp period. In the group of ten patients with negative XD before therapy, sera from eight of them displayed lytic activity. At the end of the follow-up period seven oi them became negative. Nine of the ten patients maintained their origin al condition with respect io XD. These results suggests that parasitae mia level before therapy condition could be an important parameter to consider in the chemotherapy of chronic Chagas disease.