APPLICATIONS OF THE SPIROANNULATION OF TETRALINS WITH ALKYNES - TOWARDS NEW ANTIESTROGENIC COMPOUNDS

Authors
BOYLE FT HARES O MATUSIAK ZS LI W WHITING DA
Citation
Ft. Boyle et al., APPLICATIONS OF THE SPIROANNULATION OF TETRALINS WITH ALKYNES - TOWARDS NEW ANTIESTROGENIC COMPOUNDS, Journal of the Chemical Society. Perkin transactions. I, (18), 1997, pp. 2707-2711
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
18
Year of publication
1997
Pages
2707 - 2711
Database
ISI
SICI code
0300-922X(1997):18<2707:AOTSOT>2.0.ZU;2-L
Abstract
Thermal reaction of the benzocyclobutene 17 with 4-methoxystyrene lead s to 1-cyano-2-(4-methoxyphenyl)-6-methoxytetralin dagger 19 through a n electrocyclic ring opening Diels-Alder sequence: the derived acid ch loride 20, and its analogue 10, then undergoes an unusual addition-cyc lisation reaction with alkynes catalysed by aluminium chloride, to yie ld the tricyclospirodienones 21a-c and 11a,b; the former set show mode rate aromatase inhibitory activity.