STUDIES ON THE REACTIVITY OF AZETIDIN-2-ONES IN PHOSPHATE BUFFER

Authors
WESTWOOD NJ SCHOFIELD CJ CLARIDGE TDW
Citation
Nj. Westwood et al., STUDIES ON THE REACTIVITY OF AZETIDIN-2-ONES IN PHOSPHATE BUFFER, Journal of the Chemical Society. Perkin transactions. I, (18), 1997, pp. 2725-2729
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
18
Year of publication
1997
Pages
2725 - 2729
Database
ISI
SICI code
0300-922X(1997):18<2725:SOTROA>2.0.ZU;2-M
Abstract
H-1 NMP (500 MHz) analyses repeal that in phosphate buffer, N-arylsulf onyl beta-lactams such as ethyl -nitrophenylsulfonyl)-2-oxoazetidine-4 -carboxylate and (4S)-ethyl -nitrophenylsulfonyl)-2-oxoazetidine-4-car boxylate undergo hydrolysis through (minimally) two mechanisms: via di rect hydrolysis and via an unstable acyl phosphate intermediate, The a cyl phosphate intermediates can be trapped using hydrazine.