ANOTHER PEDIGREE WITH PURE AUTOSOMAL-DOMINANT SPASTIC PARAPLEGIA (AD-FSP) FROM TIBET MAPPING TO 14Q11.2-Q24.3

The mutant in a family with autosomal-dominant spastic paresis in Nort hern Tibet was mapped by linkage analysis with several microsatellite markers to a gene locus at 14q11.2-q24.3, an area to which a few mutan ts leading to a condition with similar clinical signs have previously been mapped. The mutant observed in this pedigree probably arose de no vo. Gene loci at 2p21-p24 and 15q, which have been found for other ped igrees with dominant spastic paresis, were excluded. The data in this pedigree do not contradict the hypothesis proposed by another group th at there might be anticipation.