CISAPRIDE USE DURING HUMAN-PREGNANCY - A PROSPECTIVE, CONTROLLED MULTICENTER STUDY

The objective of this prospective multicenter study was to determine w hether cisapride is associated with increased risk of malformations, s pontaneous abortions, or decreased birthweight when used during pregna ncy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired cont rols. One hundred and twenty-nine pregnant women were exposed to cisap ride during pregnancy, including 88 during the period of fetal organog enesis, There were no differences in maternal history, birthweight, ge stational age at delivery, and rates of livebirths, spontaneous or the rapeutic abortions, fetal distress, and major or minor malformations a mong groups, It is concluded that exposure to cisapride during pregnan cy is not associated with a major increased risk of malformations or s pontaneous abortions or with decreased birthweight.