IL-10 PRODUCTION IN MULTIPLE-SCLEROSIS PATIENTS, SLE PATIENTS AND HEALTHY CONTROLS - PRELIMINARY FINDINGS

Authors
GELATI M LAMPERTI E DUFOUR A CORSINI E VENEGONI E MILANESE C NESPOLO A SALMAGGI A
Citation
M. Gelati et al., IL-10 PRODUCTION IN MULTIPLE-SCLEROSIS PATIENTS, SLE PATIENTS AND HEALTHY CONTROLS - PRELIMINARY FINDINGS, Italian journal of neurological sciences, 18(4), 1997, pp. 191-194
Citations number
12
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Italian journal of neurological sciences → ACNP
ISSN journal
03920461
Volume
18
Issue
4
Year of publication
1997
Pages
191 - 194
Database
ISI
SICI code
0392-0461(1997)18:4<191:IPIMPS>2.0.ZU;2-0
Abstract
IL-10 is a cytokine with suppressive effects on (auto) antigen present ation and T-cell-mediated immune reactions, but is also capable of sti mulating polyclonal IgG synthesis. Recent evidence suggests its involv ement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE ). We assessed PBMNC IL-10 release in MS and SLE patients before and a fter in vivo prednisone or methylprednisolone treatment. The SLE patie nts showed a high level of IL-10 release by unstimulated PBMNCs, where as the PHA-stimulated PBMNCs from MS patients produced large amounts o f the cytokine.