Because closed chest cardiopulmonary resuscitation (CCCPR) achieve res
toration of spontaneous circulation (ROSC) in less than 50% of cases,
and because of the apparent physiological superiority of open-chest ca
rdiopulmonary resuscitation (OCCPR), we evaluated OCCPR in out-of hosp
ital cardiac arrest in cases who did not respond to standard external
cardiopulmonary resuscitation with advanced life support. Over a perio
d of 12 years, OCCPR was performed in 33 patients with out-of-hospital
cardiac arrest arising from different causes: after unsuccessful atte
mpts to achieve ROSC with CCCPR efforts over 7-121 min (median 25 min)
. With OCCPR, ROSC was achieved in 13/33 patients. Of these, two recov
ered to discharge (one with no neurological deficit and one with mild
brain damage). The other 11 rearrested either in the emergency departm
ent after a median period of 70 min of resuscitation, or in the intens
ive care unit after a median period of 104 h. One case of iatrogenic c
ardiac injury was observed. The OCCPR attempts were well accepted by t
he public. Our data suggest that OCCPR is more effective than CCCPR in
achieving ROSC outside hospital in patients with major cardiac diseas
e and prolonged arrest. OCCPR is feasible in the out-of-hospital setti
ng. Survival without neurological deficit cannot be expected when CCCP
R with no-flow is continued beyond 25 min. (C) 1997 Elsevier Science I
reland Ltd.