EFFECT OF OXYGEN ON THE HYDROXYLATION OF ADENINE BY PHOTOLYTICALLY GENERATED HYDROXYL RADICAL

Authors
DIAS RMB VIEIRA AJSC
Citation
Rmb. Dias et Ajsc. Vieira, EFFECT OF OXYGEN ON THE HYDROXYLATION OF ADENINE BY PHOTOLYTICALLY GENERATED HYDROXYL RADICAL, Journal of photochemistry and photobiology. A, Chemistry, 109(2), 1997, pp. 133-136
Citations number
17
Categorie Soggetti
Chemistry Physical
Journal title
Journal of photochemistry and photobiology. A, Chemistry → ACNP
ISSN journal
10106030
Volume
109
Issue
2
Year of publication
1997
Pages
133 - 136
Database
ISI
SICI code
1010-6030(1997)109:2<133:EOOOTH>2.0.ZU;2-F
Abstract
The adduct formed in aqueous solution after the reaction of photolytic ally generated HO. radical with adenine at the C(8) position, Ade-8-OH ., is oxidized by ferricyanide or molecular oxygen to give 8-hydroxyad enine (8-OH-Ade). In the former case, Ade-8-OH. is oxidized by electro n transfer, whereas, in the latter, it undergoes oxygen addition, form ing a peroxyl radical, Ade-8-OH-O-2(.). From a comparison of the yield s of El-OH-Ade in both cases, it is found that only 34%, at most, of t he Ade-8-OH-O-2(.) radicals eliminate superoxide anion. (C) 1997 Elsev ier Science S.A.