AMPULLOSPORIN, A NEW PEPTAIBOL-TYPE ANTIBIOTIC FROM SEPEDONIUM-AMPULLOSPORUM HKI-0053 WITH NEUROLEPTIC ACTIVITY IN MICE

Authors
RITZAU M HEINZE S DORNBERGER K BERG A FLECK W SCHLEGEL B HARTL A GRAFE U
Citation
M. Ritzau et al., AMPULLOSPORIN, A NEW PEPTAIBOL-TYPE ANTIBIOTIC FROM SEPEDONIUM-AMPULLOSPORUM HKI-0053 WITH NEUROLEPTIC ACTIVITY IN MICE, Journal of antibiotics, 50(9), 1997, pp. 722-728
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
9
Year of publication
1997
Pages
722 - 728
Database
ISI
SICI code
0021-8820(1997)50:9<722:AANPAF>2.0.ZU;2-S
Abstract
Ampullosporin (I; Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) w as isolated from the mycelium of Sepedonium ampullosporum as a new 15- membered peptaibol-type antibiotic. The structure was determined by ma ss spectrometric and two-dimensional NMR experiments. Ampullosporin di splays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreas ed spontaneous locomotor activity in mice in dosages > 1 mg/kg.