MUTATIONS IN THE GYRA AND PARC GENES IN FLUOROQUINOLONE-RESISTANT CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA

Authors
NAKANO M DEGUCHI T KAWAMURA T YASUDA M KIMURA M OKANO Y KAWADA Y
Citation
M. Nakano et al., MUTATIONS IN THE GYRA AND PARC GENES IN FLUOROQUINOLONE-RESISTANT CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA, Antimicrobial agents and chemotherapy, 41(10), 1997, pp. 2289-2291
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
10
Year of publication
1997
Pages
2289 - 2291
Database
ISI
SICI code
0066-4804(1997)41:10<2289:MITGAP>2.0.ZU;2-Y
Abstract
We determined partial sequences of the gyrA and parC genes of the fluo roquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased su sceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resis tant isolates had a double amino acid change in GyrA and a single amin o acid change in ParC.