PHARMACOKINETIC STUDY OF CEFODIZIME AND CEFTRIAXONE IN SERA AND BONESOF PATIENTS UNDERGOING HIP-ARTHROPLASTY

The study was carried out to determine the concentrations of cefodizim e (single 2-g intravenous [i.v.] dose) and ceftriaxone (single 2-g i.v . dose) in the sera and bones of 42 patients (18 women and 24 men) und ergoing hip arthroplasty. The concentrations of cefodizime and ceftria xone in cancellous and cortical bone appear to be related to the free levels in serum but not to the total levels in serum, so the concentra tions of cephalosporins in bone must be compared with the free concent rations in serum. Both drugs diffuse well into bone, with concentratio ns exceeding the MIC at which 90% of the major pathogenic infecting or ganisms are inhibited.