IN-VITRO ANTIMALARIAL ACTIVITY OF PENDULINE, A BISBENZYLISOQUINOLINE FROM ISOPYRUM THALICTROIDES

Authors
VALENTIN A BENOITVICAL F MOULIS C STANISLAS E MALLIE M FOURASTE I BASTIDE JM
Citation
A. Valentin et al., IN-VITRO ANTIMALARIAL ACTIVITY OF PENDULINE, A BISBENZYLISOQUINOLINE FROM ISOPYRUM THALICTROIDES, Antimicrobial agents and chemotherapy, 41(10), 1997, pp. 2305-2307
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
10
Year of publication
1997
Pages
2305 - 2307
Database
ISI
SICI code
0066-4804(1997)41:10<2305:IAAOPA>2.0.ZU;2-3
Abstract
Two bisbenzylisoquinolines, tetrandrine and penduline, were purified f rom Isopyrum thalictroides. When tested for antimalarial activity in v itro, penduline was efficient at concentrations fivefold lower than th ose of tetrandrine. In highly synchronized parasite cultures, pendulin e mostly interfered between the 8th and the 32nd hours of the parasite cycle.