COMPARATIVE IN-VITRO ACTIVITIES OF TROVAFLOXACIN (CP-99,219) AGAINST 221 AEROBIC AND 217 ANAEROBIC-BACTERIA ISOLATED FROM PATIENTS WITH INTRAABDOMINAL INFECTIONS

Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and antimicrobial agents. T rovafloxacin inhibited 435 strains (99.3%) at less than or equal to 2 mu g/ml. All the quinolones had similar activities against Enterobacte riaceae and Pseudomonas sp., but trovafloxacin showed superior activit ies against streptococci, enterococci, and anaerobic organisms. Becaus e of its excellent in vitro activities against diverse bacteria, trova floxacin has potential use as a single agent for polymicrobial infecti ons.