AN EFFICIENT METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE 4-HYDROXY-DELTA(2)-ISOXAZOLINES

Authors
WALLACE RH LIU JC ZONG KK EDDINGS A
Citation
Rh. Wallace et al., AN EFFICIENT METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE 4-HYDROXY-DELTA(2)-ISOXAZOLINES, Tetrahedron letters, 38(39), 1997, pp. 6791-6794
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
39
Year of publication
1997
Pages
6791 - 6794
Database
ISI
SICI code
0040-4039(1997)38:39<6791:AEMFTP>2.0.ZU;2-I
Abstract
In this letter we report a method for the preparation of optically act ive 4-hydroxy-Delta(2)-isoxazoIines. This methodology relies on the us e of a camphorsultam substituted vinylboronic ester which upon nitrile oxide cycloaddition and oxidation affords the optically active 4-hydr oxy-Delta 2-isoxazolines in good yield. (C) 1997 Elsevier Science Ltd.