SODIUM PERCARBONATE - A MULTIFUNCTIONAL REAGENT FOR THE PREPARATION OF OPTICALLY-ACTIVE 4-HYDROXY-DELTA(2)-ISOXAZOLINES

Authors
LIU JC EDDINGS A WALLACE RH
Citation
Jc. Liu et al., SODIUM PERCARBONATE - A MULTIFUNCTIONAL REAGENT FOR THE PREPARATION OF OPTICALLY-ACTIVE 4-HYDROXY-DELTA(2)-ISOXAZOLINES, Tetrahedron letters, 38(39), 1997, pp. 6795-6798
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
39
Year of publication
1997
Pages
6795 - 6798
Database
ISI
SICI code
0040-4039(1997)38:39<6795:SP-AMR>2.0.ZU;2-2
Abstract
In this letter we report a general method for the preparation of optic ally active 4-hydroxy-Delta(2)-isoxazoIines. This one-pot method emplo ys sodium percarbonate for nitrile oxide generation, oxidation of the intermediate boronic ester substituted Delta(2)-isoxazoline, and cleav age of the chiral auxiliary from the final product. (C) 1997 Elsevier Science Ltd.