ENANTIOMERIC SEPARATION OF CARBOXYLIC-ACIDS HAVING CHIRAL CENTERS REMOTE FROM THE CARBOXYL GROUP BY LABELING WITH A CHIRAL FLUORESCENT DERIVATIZATION REAGENT

Enantiomeric separations of 2-, 3-, 4-, 5- and 6-methyl fatty acids an d 3-, 4- and 5-hydroxy fatty acids derivatized with (S)-(+)-2-(anthrac ene-2,3-dicarboximido)-1-propyl trifluoromethanesulfonate are describe d. Although there are 4-8 bond distances between the chiral centers of these diastereomeric derivatives, they are separated on HPLC and dete cted at fmol levels. (C) 1997 Elsevier Science Ltd.