CLINICAL-SIGNIFICANCE OF THE DNA INDEX IN HEMATOGENOUS DISSEMINATION OF ANEUPLOID COLORECTAL-CANCER

Authors
YAMAMOTO T MATSUMOTO K YAMAMOTO J KITAGAWA T MIKI C IRIYAMA K SUZUKI H
Citation
T. Yamamoto et al., CLINICAL-SIGNIFICANCE OF THE DNA INDEX IN HEMATOGENOUS DISSEMINATION OF ANEUPLOID COLORECTAL-CANCER, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 27(10), 1997, pp. 973-974
Citations number
6
Categorie Soggetti
Surgery
Journal title
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY → ACNP
ISSN journal
09411291
Volume
27
Issue
10
Year of publication
1997
Pages
973 - 974
Database
ISI
SICI code
0941-1291(1997)27:10<973:COTDII>2.0.ZU;2-S
Abstract
The DNA index (DI), defined as the ratio of the G(0)/G(1) channel numb er of tumor cells to the G(0)/G(1) channel number of stromal cells, wa s analysed in 121 aneuploid colorectal cancers. In patients,vith aneup loid tumors, a high DI significantly correlated with tumor penetration beyond the proper muscle layer, positive vascular invasion, and the p resence of liver metastasis. This observation led us to conclude that a high DI is likely to be associated with hematogenous dissemination i n aneuploid colorectal cancer.