S. Hanyu et al., TOPOGRAPHICAL ANALYSIS OF CORTICAL NEURONAL LOSS ASSOCIATED WITH DISSEMINATED SELECTIVE NEURONAL NECROSIS AND INFARCTION AFTER REPEATED ISCHEMIA, Brain research, 767(1), 1997, pp. 154-157
A study was carried out of the distribution and density of the neurons
remaining in the gerbil cerebral cortex following two 10-min periods
of ischemia at either 3-, 5- or 48-h intervals. As the interval betwee
n the periods of ischemia increased, the ischemic injury was reduced f
rom severe to milder infarction, and further from more to less intense
disseminated selective neuronal necrosis. This model is suitable for
studying the mechanisms of transition from selective neuronal necrosis
to infarction at the threshold level of infarction. (C) 1997 Elsevier
Science B.V.