SYNTHESIS OF 4'-C-FLUOROMETHYLNUCLEOSIDES AS POTENTIAL ANTINEOPLASTICAGENTS

Authors
KITANO K MIURA S OHRUI H MEGURO H
Citation
K. Kitano et al., SYNTHESIS OF 4'-C-FLUOROMETHYLNUCLEOSIDES AS POTENTIAL ANTINEOPLASTICAGENTS, Tetrahedron, 53(39), 1997, pp. 13315-13322
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
39
Year of publication
1997
Pages
13315 - 13322
Database
ISI
SICI code
0040-4020(1997)53:39<13315:SO4APA>2.0.ZU;2-I
Abstract
2-Deoxy-D-erythro-, ribo-, and arabino-pentofuranosylcytosines, which have a fluoromethyl group at the 4'-position, were synthesized. Introd uction of fluorine was achieved by DAST treatment of 4-C-hydoxymethyl- D-ribofuranose, the key intermediate of 4'-C-methyl-nucleosides. Among these nucleosides, the 2'-deoxy derivative exhibited potent antineopl astic activity in vitro. (C) 1997 Published by Elsevier Science Ltd.