2-Deoxy-D-erythro-, ribo-, and arabino-pentofuranosylcytosines, which
have a fluoromethyl group at the 4'-position, were synthesized. Introd
uction of fluorine was achieved by DAST treatment of 4-C-hydoxymethyl-
D-ribofuranose, the key intermediate of 4'-C-methyl-nucleosides. Among
these nucleosides, the 2'-deoxy derivative exhibited potent antineopl
astic activity in vitro. (C) 1997 Published by Elsevier Science Ltd.