THE EFFECT OF ALPHA-TRINOSITOL ON CHOLERA TOXIN-INDUCED FLUID ACCUMULATION IN PIG (SUS SCROFA DOMESTICUS) JEJUNUM IN-VIVO

Authors
TINDHOLDT TT HANSEN MB ELBROND VS MAKINDE M WESTERBERG EJ SKADHAUGE E
Citation
Tt. Tindholdt et al., THE EFFECT OF ALPHA-TRINOSITOL ON CHOLERA TOXIN-INDUCED FLUID ACCUMULATION IN PIG (SUS SCROFA DOMESTICUS) JEJUNUM IN-VIVO, Comparative biochemistry and physiology. Section A: Comparative physiology, 118(2), 1997, pp. 305-307
Citations number
20
Categorie Soggetti
Physiology,Biology
Journal title
Comparative biochemistry and physiology. Section A: Comparative physiology
ISSN journal
10956433 → ACNP
Volume
118
Issue
2
Year of publication
1997
Pages
305 - 307
Database
ISI
SICI code
1095-6433(1997)118:2<305:TEOAOC>2.0.ZU;2-8
Abstract
The effect of alpha-trinositol (D-myo-inositol-1,2,6-trisphosphate) on cholera toxin-induced fluid accumulation (i.e., net fluid secretion) was studied in the pig jejunum in vivo. Cholera toxin caused a dose-de pendent fluid accumulation in control experiments. Intravenous injecti on of alpha-trinositol produced a reduction of the response to cholera toxin with a significant maximal inhibition of 36%. However, in high concentrations of alpha-trinositol this inhibition was absent. (C) 199 7 Elsevier Science Inc.