AN EFFICIENT METHOD FOR THE SYNTHESIS OF (R)-3-(1-AMINO-1-METHYLETHYL)PYRROLIDINES FOR THE ANTIINFECTIVE AGENT, PD-138312

Authors
FEDIJ V LENOIR EA SUTO MJ ZELLER JR WEMPLE J
Citation
V. Fedij et al., AN EFFICIENT METHOD FOR THE SYNTHESIS OF (R)-3-(1-AMINO-1-METHYLETHYL)PYRROLIDINES FOR THE ANTIINFECTIVE AGENT, PD-138312, Tetrahedron : asymmetry, 5(7), 1994, pp. 1131-1134
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
7
Year of publication
1994
Pages
1131 - 1134
Database
ISI
SICI code
0957-4166(1994)5:7<1131:AEMFTS>2.0.ZU;2-A
Abstract
Methylcerium dichloride has been found to undergo bis addition to nitr iles to produce tertiary carbinamines with retention of optical purity at the a position. This result is used in the development of a short, economical synthesis of the 1,8-naphthyridine antiinfective agent, PD 138312.