PLASMA INTERLEUKIN-8, INTERLEUKIN-10, AND E-SELECTIN LEVELS IN NEUTROPENIC AND NON-NEUTROPENIC BACTEREMIC PATIENTS

Plasma interleukin-8 (IL-8), interleukin-10 (IL-10), and E-selectin co ncentrations were studied in 39 neutropenic and 30 non-neutropenic bac teremic patients; 54 nonbacteremic patients were analyzed as controls, Interleukin-8 concentrations were significantly higher in neutropenic than in non-neutropenic bacteremic patients (median 475 vs, 0 pg/ml, p < 0.0001), Median IL-8 and IL-10 levels were higher in bacteremic th an in non-bacteremic patients (330 vs, 0 pg/ml, p < 0.0001 and 20 vs, 0 pg/ml, p = 0.04, respectively), In contrast, concentrations of IL-10 were similar in neutropenic and non-neutropenic patients, Median leve ls of E-selectin were not increased in any of the patient groups, Neut ropenic bacteremic patients showed significantly lower concentrations of E-selectin than did non-neutropenic bacteremic patients (p < 0.0001 ), In conclusion, neutropenic bacteremic patients had significantly hi gher concentrations of IL-8 than non-neutropenic bacteremic patients, Levels of IL-10 were higher in bacteremic than in nonbacteremic patien ts, but neutropenic and non-neutropenic patients had similar levels of IL-10, Increased levels of E-selectin were not found in any of the pa tient groups, although neutropenic patients with bacteremia had lower concentrations than did non-neutropenic patients.