DRIVING PROTEINS OFF DNA USING APPLIED TENSION

Authors
MARKO JF SIGGIA ED
Citation
Jf. Marko et Ed. Siggia, DRIVING PROTEINS OFF DNA USING APPLIED TENSION, Biophysical journal, 73(4), 1997, pp. 2173-2178
Citations number
41
Categorie Soggetti
Biophysics
Journal title
Biophysical journal → ACNP
ISSN journal
00063495
Volume
73
Issue
4
Year of publication
1997
Pages
2173 - 2178
Database
ISI
SICI code
0006-3495(1997)73:4<2173:DPODUA>2.0.ZU;2-Z
Abstract
Proteins that bind DNA so as to reduce its end-to-end length can be di ssociated by application of force. The thermodynamics of this process are discussed, with special attention to the case of histones bound to DNA (i.e., a string of nucleosomes, or chromatin fiber). The histone octamer is predicted to be driven off chromatin fiber for tensions >2 piconewtons.