CHEMICAL-REACTIONS ON POLYSACCHARIDES .7. SULFONAMIDE DERIVATIVES OF DEXTRAN

The amidation reaction of linear and crosslinked sulfopropyl dextran w ith protic and dipolar aprotic amidic solvents such as formamide, N,N- dimethylformamide, N,N-dimethylacetamide and hexamethylphosphoramide, at mild temperature, was studied. The composition of the final product s can be adjusted by molar ratios. of reagents, temperature and durati on of reaction. The final products are water-soluble or highly water-s wellable hydrogels which possess an ion-exchange ability due to their content of unreacted sulfonic acid groups. Some physico-chemical chara cteristics of these new polymers are pointed out.