THERMOANALYTICAL STUDY OF CORTICOSTEROID ADSORPTION DESORPTION ON A CELLULOSIC POLYMER/

Authors
GALLARDO V GARCIA E RUIZ MA
Citation
V. Gallardo et al., THERMOANALYTICAL STUDY OF CORTICOSTEROID ADSORPTION DESORPTION ON A CELLULOSIC POLYMER/, Reactive & functional polymers, 34(1), 1997, pp. 127-134
Citations number
8
Categorie Soggetti
Polymer Sciences","Engineering, Chemical","Chemistry Applied
Journal title
Reactive & functional polymers → ACNP
ISSN journal
13815148
Volume
34
Issue
1
Year of publication
1997
Pages
127 - 134
Database
ISI
SICI code
1381-5148(1997)34:1<127:TSOCAD>2.0.ZU;2-X
Abstract
The aim of this work was to study the adsorption/desorption processes of two corticosteroids (6-methylprednisolone and sodium hemisuccinate of 6-methylprednisolone) on a cellulosic polymer of ethylcellulose, th e commercial latex, Aquacoat(R). We measured the time, pH and concentr ation of the drug necessary to produce the best adsorption and its sub sequent release. The data were obtained with spectrophotometry and dif ferential scanning calorimetry. Several overlapping mechanism appeared be involved in the adsorption of the drugs. Identification of these m echanisms helped to determine the best conditions for adsorption, and to predict degradation of the drugs.