Intracranial or spinal epidural hematomas are almost always of post-tr
aumatic origin, and rarely related to rupture of a dural vascular malf
ormation or a hemostasis disorder. We report a case of spontaneous cer
ebral epidural hematoma observed in a young girl with homozygous sickl
e cell disease. After analysis of post-operative cerebral MRI, showing
skull bone infarction inside and around the bone flap, it was conside
red that the skull bone infarction could be responsible for a diploic
venous thrombosis with subsequent ''spontaneous'' epidural hematoma.