EFFECT OF DEMETHYLATION ON THE CHITINASE INHIBITORY ACTIVITY OF ALLOSAMIDIN

Authors
SPINDLER KD SPINDLERBARTH M SAKUDA S
Citation
Kd. Spindler et al., EFFECT OF DEMETHYLATION ON THE CHITINASE INHIBITORY ACTIVITY OF ALLOSAMIDIN, Archives of insect biochemistry and physiology, 36(3), 1997, pp. 223-227
Citations number
11
Categorie Soggetti
Entomology,Biology,Physiology
Journal title
Archives of insect biochemistry and physiology → ACNP
ISSN journal
07394462
Volume
36
Issue
3
Year of publication
1997
Pages
223 - 227
Database
ISI
SICI code
0739-4462(1997)36:3<223:EODOTC>2.0.ZU;2-P
Abstract
Removal of a methyl group of the allosamizoline moiety of allosamidin decreases the inhibitory effect on family 18 chitinases from three dif ferent species (a bacterium, Serratia marcescens, a crustacean, Artemi a salina, and an insect cell line, Chironomus tentans). Loss of a seco nd methyl group weakens enzyme inhibition further. This is in agreemen t with the highly conserved catalytic centre of these enzymes. (C) 199 7 Wiley-Liss, Inc.