M. Karvonen et al., REGIONAL DIFFERENCES IN THE INCIDENCE OF INSULIN-DEPENDENT DIABETES-MELLITUS AMONG CHILDREN IN FINLAND FROM 1987 TO 1991, Annals of medicine, 29(4), 1997, pp. 297-304
The regional pattern of insulin-dependent diabetes mellitus (IDDM) inc
idence among children in Finland was analysed applying several methods
attempting to describe the geographical variation in occurrence of ID
DM. From 1987 to 1991 the number of newly diagnosed cases aged 14 year
s or less at diagnosis was 1728. The incidence, the incidence rate rat
io and the Bayes relative risk (RR) for IDDM were calculated by munici
pality, by functional area (an urban centre with a subordinated surrou
nding area) and by area with a population of equal size at risk employ
ing the Geographical Information Systems. The association of IDDM inci
dence with the degree of urbanization was assessed using the populatio
n density as a criterion for the degree of urbanization. The overall m
ean of the IDDM incidence was 35 per 100000 persons per year. Between
municipalities the incidence varied from 4 to 245 per 100000 persons p
er year, whereas a clear regional pattern was seen among the functiona
l areas and the incidence varied from 26 to 43 per 100000 persons per
year. The RR for IDDM among the municipalities ranged from 0.82 to 1.3
4 and from 0.73 to 1.27 among the functional areas. The incidence dete
rmined in four zones with the same size of population was the highest
in the middle part of the country. There was a strong inverse correlat
ion between population density and the incidence of IDDM and this also
applied to the relationship between child population density and inci
dence.