Ck. Chan et al., STUDY OF HYGROSCOPIC PROPERTIES OF AQUEOUS MIXTURES OF DISODIUM FLUORESCEIN AND SODIUM-CHLORIDE USING AN ELECTRODYNAMIC BALANCE, Pharmaceutical research, 14(9), 1997, pp. 1171-1175
Purpose, The purposes of this study are: a) to demonstrate the use of
an Electrodynamic Balance (EDB) to investigate the hygroscopic propert
ies of pharmaceutical aerosols; and b) to evaluate the applicability o
f the Zdanovskii-Stokes-Robinson model (ZSR) in the associated data an
alysis with multicomponent pharmaceutical aerosols. Methods. The compo
sitional dependence of the water activity of two model materials commo
nly employed in the study of pharmaceutical aerosols, namely, NaCl and
Disodium Fluorescein(DF), was investigated using an EDB. The water co
ntents of single levitated droplets of NaCl and DF and their mixtures
at mass ratios of 1:3, 1:1, 3:1, and 6:1 from dilute concentration to
high supersaturation were determined as a function of relative humidit
y (RH). Results. At decreasing ambient RH, supersaturated aqueous NaCl
droplets lose water and crystallize to form dry solid particles at an
RH of similar to 50%. Aqueous DF droplet continues to lose water unti
l it reaches a final state containing about 20% by mass of residual wa
ter. Mixed solutions of DF and NaCl crystallize at an RH of similar to
50% and then continue to lose water at lower RHs. The resulting ''dri
ed'' particle still contains water whose amount depends on the mass ra
tios of DF and NaCl in the mixture. Good prediction of water activity
of the DF-NaCl mixture can be achieved with the ZSR model. Collection
of a full set of water activity-composition data at each mass ratio of
DF-NaCl requires only a few hours. Conclusions. The EDB, together wit
h the application of the ZSR model in data treatment, appears to be a
valuable tool for studying the hygroscopic properties of pharmaceutica
l aerosols.