MASSIVE CUTANEOUS MUCINOSIS ASSOCIATED WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

We describe a 23-year-old Japanese man with systemic lupus erythematos us (SLE) who developed massive cutaneous mucinosis. Ile was diagnosed with SLE when he was ii years old, Prednisolone therapy (30 mg/day) wa s initiated and reduced to 10 mg/day 3 months later: the SLE had been well controlled with this dose of prednisolone for 12 years, However, infiltrated erythematous plaques developed on the middle-lateral area of his back at 17 years old and progressed to erythematous and elastic soft tumorous masses over 20 cm in diameter at 23 years old, Biopsies of the lesions on the nape revealed massive mucin deposition, Topical injection with hyaluronidase decreased the lesion, This cutaneous muc inosis can be distinguished clinically and histopathologically from pa pular and nudular mucinosis associated with SLE, The present case migh t be an unusual clinical variant of cutaneous mucinosis associated wit h SLE.