EWING SARCOMA METASTATIC TO THE IRIS

PURPOSE: To report a case of Ewing sarcoma metastatic to the iris. MET HODS: A 19-year-old woman with metastatic Ewing sarcoma of the femur d eveloped a diffuse, fluffy iris mass with a pseudohypopyon in the left eye. A fine-needle aspiration biopsy confirmed iris metastasis, and e xternal beam radiotherapy was given to the affected eye. RESULTS: The iris mass responded initially to external beam radiotherapy and ongoin g chemotherapy with vincristine, cyclophosphamide, doxorubicin, etopos ide, and ifosfamide but recurred 5 months later. Subsequent radiothera py with an iodine 125 plaque achieved further resolution of the iris t umor. CONCLUSIONS: Ewing sarcoma can rarely metastasize to the iris. T he diagnosis can be confirmed by fine-needle aspiration biopsy. Plaque radiotherapy is a therapeutic alternative.