DEVELOPMENT AND STUDY OF IMMUNOGLOBULIN PROTECTING FROM LASSA FEVER

Authors
KRASNYANSKY VP GRADOBOYEV VN BORISEVICH IV POTRYVAYEVA NV LEBEDINSKAYA YV CHERNIKOVA NK TIMANKOVA GD
Citation
Vp. Krasnyansky et al., DEVELOPMENT AND STUDY OF IMMUNOGLOBULIN PROTECTING FROM LASSA FEVER, Voprosy virusologii, 42(4), 1997, pp. 168-171
Citations number
15
Categorie Soggetti
Virology
Journal title
Voprosy virusologii → ACNP
ISSN journal
05074088
Volume
42
Issue
4
Year of publication
1997
Pages
168 - 171
Database
ISI
SICI code
0507-4088(1997)42:4<168:DASOIP>2.0.ZU;2-G
Abstract
A horse may serve the producer of immune antiserum to Lassa virus. Spe cific immunoglobulin with at least 1:512 titer of virus-neutralizing a ntibodies to Lassa fever was obtained by alcohol sedimentation after C ohn from the blood serum of immunized horses. The preparation does not differ from heterologous commercial immunoglobulins. Preclinical stud ies of immunoglobulin to Lassa fever demonstrated its safety and a hig h specific activity. The agent can be injected both alone and in combi nation with virasole.