A patient with a commun variable immunodeficiency (CVID) is hospitaliz
ed for chronic symptoms of malabsorption (weigh loss and diarrhea). Th
e duodenal histology show a total villous atrophy. Investigations are
negative and a gluten free diet is given. Symptoms of malabsorption di
sappear and improvement is histologically confirmed. Our observation s
uggest that the coincidence of gluten sensitive enteropathy and CVID i
s possible and clinicians should be aware of this association and shou
ld consider giving a gluten free diet. The sensitivity of serologic te
sting in this conditions is unknown.