PREPARATION OF NEW NUCLEOSIDE ANALOGS FROM 3,6-ANHYDROSUGARS

Authors
SERRANO JA JIMENEZ M ROMAN E
Citation
Ja. Serrano et al., PREPARATION OF NEW NUCLEOSIDE ANALOGS FROM 3,6-ANHYDROSUGARS, Journal of carbohydrate chemistry, 16(7), 1997, pp. 1051-1059
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Journal of carbohydrate chemistry → ACNP
ISSN journal
07328303
Volume
16
Issue
7
Year of publication
1997
Pages
1051 - 1059
Database
ISI
SICI code
0732-8303(1997)16:7<1051:PONNAF>2.0.ZU;2-3
Abstract
-(3,6-Anhydro-2-deoxy-alpha-D-glucofurano)pyridine (2a), N-(o-phenylen e)-2-deoxy-alpha-D-allofuranosylamine (4) and ydro-1-deoxy-D-arabino-p entitol-1-yl)benzimidazole (8) were synthesized by reaction of 2-amino pyridine or o-phenylenediamine with 3,6-anhydro-2-deoxy-D-glucose. For mation of compound (4) is explained through a Michael-type addition of the o-phenylenediamine on the intermediate alpha,beta-unsaturated car bohydrate aldehyde (7).