IDIOPATHIC AND SYMPTOMATIC HYPEREOSINOPHILIC SYNDROMES (COMPARATIVE CHARACTERISTICS OF 14 CASES)

Clinical, hematological, cytogenetic and pathohistological findings in 14 patients with high eosinophilia allowed the authors to distinguish 2 groups of patients: with symptomatic (secondary) and idiopathic hyp ereosinophilic syndromes (6 and 8 patients, respectively). The latter was characterized by hepato-and splenomegaly, specific cardiac lesion (thromboplastic endocarditis), non-infectious fever, anemia and thromb ocytopenia, marked hypercellularity of the bone marrow with inhibition of erythro-and megakaryocytopoiesis. Ph'-chromosome occurred in 2 out of 8 cases. Biopsy and autopsy histology in all cases of idiopathic h ypereosinophilic syndrome were typical for myeloproliferative diseases . In symptomatic hypereosinophilic syndrome the above features were no t registered.